74857-4

West Nile virus RNA [Presence] in Serum or Plasma from Donor by NAA with probe detection

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Term Description

A qualitative in vitro nucleic acid screening test for the direct detection of West Nile Virus (WNV) RNA in human plasma. This test screens donor samples for west nile virus RNA in plasma from individual human donors, including donors of whole blood, blood components and other living donors. This test also screens organ and tissue donors when donor samples are obtained while the donor's heart is still beating, and in testing cadaveric (non-heart-beating) donors. Not intended for use on samples of cord blood. Plasma from all donors may be screened as individual specimens. For donations of whole blood and blood components, plasma samples may be tested individually or in pools comprised of not more than six individual samples. For donations from cadaveric (non-heart-beating) organ and tissue donors, samples may only be screened as individual specimens. Not intended for use in the diagnosis of infection with WNV. This term was based on, but not limited in use to, the cobas West Nile Virus RNA assay.
Source: Regenstrief LOINC

Part Description

LP28423-9 West Nile virus
The West Nile Virus (WNV) is an arbovirus that was first identified in the West Nile District of Uganda in 1937. In the fall of 1999, the National Veterinary Services Laboratory (NVLS) isolated WNV in a dead crow in New York City.(http://www.who.int/mediacentre/factsheets/fs354/en/) Over the following ten years, WNV spread throughout the United States, Canada, Mexico and the Carribbean. WNV is usually transmitted through the bite of the Culex mosquito, but can also be spread in blood transfusions, organ transplants, breast milk, intrauterine exposure and laboratory-acquired infections. Birds are the preferred host of WNV, and the American robin is an important amplifier host since it develops enough virus in its serum to infect feeding mosquitoes. Though most infections with WNV are subclinical for humans, between 2005 and 2009 there were 12,975 people infected with WNV, of which 35% had severe cases of neuroinvasive disease and 496 people died. For individuals who are 70 years of age or older, infection with WNV has a 15-29% fatality rate. For infants and immunocompromised patients infected with WNV, the fatality rate is even higher. Diagnosis of WNV is based on clinical symptoms and antibody titers. The IgM antibody-capture enzyme-linked immunosorbent assay (MAC-ELISA) is the key method used to diagnosis WNV in clinical settings. Antibody titers to WNV NS5 are detectable long-term in vivo and can be used to distinguish past infection with WNV from current infection. RNA is usually undetectable in serum after 13.2 days, but on rare occasions, has been found in serum beyond 40 days. Treatment of infection with WNV is mostly supportive. There are no FDA-approved drugs or vaccines available. PMID: 12089283 PMID: 23034323 Source: Regenstrief LOINC

Fully-Specified Name

Component: West Nile Virus RNA
Property: PrThr
Time: Pt
System: Ser/Plas^Donor
Scale: Ord
Method: Probe.amp.tar

Additional Names

Short Name: WNV RNA SerPl Donr Ql NAA+probe
Display Name: West Nile virus RNA NAA+probe Ql (S/P donor)
Consumer Name Alpha Get Info: West Nile virus, Donor Blood

Example Answer List: LL2888-7

Source: Roche Diagnostics International

Answer	Code	Score	Answer ID
NonreactiveCopyright http://snomed.info/sct ID:131194007 Non-reactive (qualifier value)			LA15256-3
ReactiveCopyright http://snomed.info/sct ID:11214006 Reactive (qualifier value)			LA15255-5
InvalidCopyright http://snomed.info/sct ID:455371000124106 Invalid result (qualifier value)			LA15841-2

Basic Attributes

Class: MICRO
Type: Laboratory
First Released: Version 2.48
Last Updated: Version 2.63
Change Reason: The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation: Both

Language Variants Get Info

Tag	Language	Translation
de-DE	German (Germany)	West-Nil-Virus RNA:Nachweis oder Schwellenwert:Zeitpunkt:Serum oder Plasma^Donor:Ordinal:Zielfragmentamplifikation mit Sondendetektion
es-ES	Spanish (Spain)	Virus Nilo Occidental RNA:PrThr:Punto temporal:Suero o Plasma^donante:Ord:Sonda con amplificación dirigida
es-MX	Spanish (Mexico)	ARN del virus del Nilo Occidental:Presencia o umbral:Punto temporal:Suero o plasma ^ Donante:Ordinal:Amplificación de ácidos nucleicos con detección de sonda
fr-CA	French (Canada)	Virus du Nil occidental , ARN:Présence-Seuil:Temps ponctuel:Sérum/Plasma^Donneur:Ordinal:Sonde avec amplification de la cible
fr-FR	French (France)	West Nile virus ARN:Présence/Seuil:Ponctuel:Sérum/Plasma du donneur:Qualitatif:PCR amplification de cible
fr-BE	French (Belgium)	Virus du Nil occidental ARN:PrThr:Temps ponctuel:Sérum/Plasma^Donneur:Ordinal:Sonde avec amplification de la cible
it-IT	Italian (Italy)	Nilo occidentale, virus RNA:PrThr:Pt:Siero/Plasma^donatore:Ord:Sonda.amp.tar Synonyms: Microbiologia Plasma Presenza o Soglia Punto nel tempo (episodio) Siero Siero o Plasma Sonda con amplificazione Sonda con amplificazione del target Sonda di DNA Virus del Nilo occidentale
nl-NL	Dutch (Netherlands)	West-Nijlvirus RNA:aanwezigheid:moment:serum of plasma^donor:ordinaal:probe-detectie Synonyms: probe.amp.tar
pt-BR	Portuguese (Brazil)	Vírus do Nilo Ocidental RNA::Pt:Soro/Plas^doador:Ord:Sonda com limite de detecção da amplificação de alvo
ru-RU	Russian (Russian Federation)	Западный Нил вирус РНК:PrThr:ТчкВрм:Сыв/Плаз^донор:Пор:Проба.усил.миш Synonyms: ДНК проба;ДНК зонд Плазма Порядковый Проба с мишени усилением Сыворотка Сыворотка или Плазма Точка во времени;Момент
tr-TR	Turkish (Turkey)	Batı Nil virüsü RNA:MevcEşik:Zmlı:Ser/Plaz^verici:Srl:Prob.amf.hdf Synonyms: Mevcut
zh-CN	Chinese (China)	西尼罗河病毒 RNA:存在情况或阈值:时间点:血清/血浆^供体:序数型:探针法.基因扩增.靶向 Synonyms: WNV RNA WNV;西尼罗河热;西尼罗河热病毒传染毒;传染毒素;滤过性病原体;病毒类;过滤性病原体供血者;捐献者;捐赠者;给予体;给体;超系统 - 供体依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型借助扩增的探针方法;借助扩增的探针法;探针法.扩增借助靶向扩增的探针方法;借助靶向扩增的探针法;探针法.扩增.靶向存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值）微生物学;微生物学试验;微生物学试验（培养、DNA、抗原及抗体）扩增型扩增性时刻;随机;随意;瞬间核糖核酸;Ribonucleic acid 经过扩增的脱氧核糖核酸探针血清/血浆^捐赠者血清或血浆西尼罗河热病毒 RNA

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