Version 2.77

Term Description

The quantitative levels (corrected for background) for an IFN-gamma response by CD4+ T-helper and CD8+ T cytotoxic lymphocytes stimulated by the presence of TB antigens, specifically ESAT-6 and CFP-10. This term was created for, but not limited in use to, the QuantiFERON-TB Gold Plus test, which includes two tubes with the Mycobacterium tuberculosis (MTB)-complex-associated antigens ESAT-6 and CFP-10 that stimulate a cell-mediated immunity (CMI) response. The first tube contains antigens that stimulate a response from CD4+ T-helper lymphocytes [LOINC: 64084-7], and the second tube (this term) contains the antigens included in tube 1 as well as an additional set of peptides targeting the CMI response from CD8+ cytotoxic T lymphocytes. In the QuantiFERON-TB Gold Plus test, the amount of IFN-gamma is measured by enzyme-linked immunosorbent assay and reported in IU/mL. Results are adjusted for background, heterophile antibody effects, or nonspecific IFN-gamma in blood samples.
Source: Regenstrief LOINC

Part Descriptions

LP14443-3   CD4
Found on helper T-cells; weakly expressed on monocytes.
Associated with some mature T-cell neoplasms, including most cases of T-cell CLL/prolymphocytic leukemia, peripheral
T-cell lymphoma, adult T-cell leukemia/lymphoma and Sézary syndrome/mycosis fungoides Source: Regenstrief LOINC

LP17729-2   CD8
Found on T-suppressor/cytotoxic cells and some Natural Killer cells; Associated with some mature T-cell neoplasms; Large granular lymphocytosis Source: Regenstrief LOINC

Fully-Specified Name

Component
Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ and CD8+ T-cells^^corrected for background
Property
ACnc
Time
Pt
System
Bld
Scale
Qn
Method

Additional Names

Short Name
M TB IFN-g CD4+CD8+ bckgrnd cor Bld-aCnc
Display Name
M. tuberculosis stim IFN-g by CD4+ CD8+ T-cells corrected for background Qn (Bld)
Consumer Name Alpha Get Info
Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ and CD8+ T-cells Corrected for Background, Blood

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.64
Last Updated
Version 2.73
Change Reason
Changed Component from Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ and CD8+ T-cells^^corrected for background to Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ and CD8+ T-cells^^corrected for background to be consistant with LOINC cell marker naming conventions.
Order vs. Observation
Both
Common Test Rank Get Info
620

Member of these Panels

LOINC Long Common Name
71775-1 Mycobacterium tuberculosis stimulated gamma interferon panel - Blood

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) IFNγ liberado por células T CD4 y T CD8 estimuladas por Mycobacterium tuberculosis^^Corregido por ruido de fondo:Concentración arbitraria:Punto temporal:Sangre:Qn:
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Mycobacterium tuberculosis estimuló la liberación de interferón gamma por células T CD4 + y CD8 +^^ corregido para antecedentes:Concentración arbitraria:Punto temporal:Sangre:Cuantitativo:
fr-FR French (France) Interféron gamma libéré par cellules T CD4+ et CD8+ stimulées par mycobacterium tuberculosis corrigé par bruit de fond:Arbitraire/Volume:Ponctuel:Sang:Numérique:
it-IT Italian (Italy) Mycobacterium tuberculosis, gamma interferone stimolato rilascio da CD4+ e CD8+ e cellule T^^corretto per background:ACnc:Pt:Sangue:Qn:
Synonyms: Concentrazione Arbitraria Gamma interferone stimolato da Mycobacterium tuber Micobatterio della tubercolosi Microbiologia Punto nel tempo (episodio) Sangue
nl-NL Dutch (Netherlands) Mycobacterium tuberculosis-gestimuleerde gamma-interferon-release door CD4+ en CD8+T-cellen^^gecorrigeerd voor achtergrond:eenheid/volume:moment:bloed:kwantitatief:
zh-CN Chinese (China) CD4+ 和 CD8+ T-细胞所释放的结核分枝杆菌刺激型 gamma 干扰素^^经过针对本底而校正的:任意型浓度:时间点:全血:定量型:
Synonyms: AFB CD4+ 和 CD8+ T-细胞（CD4+ 和 CD8+ T细胞、CD4+ 和 CD8+ T淋巴细胞）所释放的结核分枝杆菌刺激型 gamma 干扰素（γ干扰素、IFN-γ） IFN L3T4 Leu2 Leu-2 Leu3 Leu-3 T4 T-4 T8 T-8 Tsuppressor W3/25 任意型浓度(单位体积);任意浓度;单位体积的任意单位数;人工型浓度 分支杆菌 分支杆菌属 分枝杆菌属 劳瘵 发现于 抑制性 T-细胞/细胞毒性 T-细胞、一些 NK 细胞之上。与一些成熟 T-细胞肿瘤和大颗粒淋巴细胞增多症相关 发现于辅助 T-细胞；微弱表达于单核细胞。与相关。一些成熟 T-细胞肿瘤，包括大多数情况下的 T-细胞慢性淋巴细胞白血病/前淋巴细胞白血病、外周 T-细胞淋巴瘤、成人 T-细胞白血病/淋巴瘤以及 Sézary 综合征（T 细胞红皮病）/蕈样肉芽肿（mycosis fungoides）。 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 微生物学;微生物学试验;微生物学试验（培养、DNA、抗原及抗体） 抑制性 T 细胞 抑制性 T-细胞 抗酸 抗酸杆菌 抗酸杆菌（Acid fast bacillus，AFB） 抗酸菌 时刻;随机;随意;瞬间 痨 痨病 细胞含量;细胞性;细胞性质;细胞构成;细胞类 经过针对背景而校正的 结核 结核;肺结核;痨;痨病;TB 结核分支杆菌;结核杆菌;结核菌 结核分枝杆菌刺激型 gamma 干扰素（γ干扰素、IFN-γ） 结核病 肺结核 血;血液 诱导 T 细胞 诱导性 T 细胞 辅助 T 细胞 辅助诱导 T 细胞 辅助诱导物 T 细胞

Example Units

Unit Source
[IU]/mL Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=88517-8