Version 2.77

Term Description

The CD154 expression and function panel is intended to screen for X-linked hyper-IgM syndrome, which results from mutations causing decreased expression or function of CD154 (the CD40 ligand expressing on the surface of T cells). The test is usually performed in male patients younger than 10 years of age or ascertaining carrier status in females of child-bearing age.
Source: Regenstrief LOINC

Part Description

LP428359-6   CD154 expression & function panel
CD154, also called CD40 ligand or CD40L, is a protein that is primarily expressed on activated T cells and is a member of the TNF family of molecules. It binds to CD40 on antigen-presenting cells (APC), which leads to many effects depending on the target cell type. In general, CD40L plays the role of a costimulatory molecule and induces activation in APC in association with T cell receptor stimulation by MHC molecules on the APC. The protein encoded by this gene is expressed on the surface of T cells. It regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene, which could result in either reduced expression or normal expression with reduced functional binding to CD40, results in an inability to undergo immunoglobulin class switch and is associated with hyper-IgM syndrome. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, CD154

Panel Hierarchy

Details for each LOINC in Panel LHC-Forms

LOINC Name R/O/C Cardinality Example UCUM Units
98239-7 CD154 expression and function panel - T cells by Flow cytometry (FC)
Indent98240-5 CD154 cells [Presence] in T cells
Indent98241-3 CD154 function (binding to CD40) [Presence] in T cells
Indent69052-9 Flow cytometry specialist review of results

Fully-Specified Name

Component
CD154 expression & function panel
Property
-
Time
Pt
System
T cells
Scale
-
Method
Flow cytometry

Additional Names

Short Name
CD154 Expr+Func Pnl T cells FC
Display Name
CD154 expression and function panel FC (T cells)
Consumer Name Alpha Get Info
CD154 expression and function panel, T cells

Basic Attributes

Class
PANEL.CELLMARK
Type
Laboratory
First Released
Version 2.71
Last Updated
Version 2.71
Order vs. Observation
Order
Panel Type
Panel

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Panel de expresión y función de CD154:Propiedades mixtas (sólo paneles):Punto temporal:Células T:-:Citometria de flujo (FC)
fr-FR French (France) CD154 expression et fonction panel:-:Ponctuel:Lymphocytes T:-:Cytométrie de flux
it-IT Italian (Italy) CD154 espressione & funzione, panel:-:Pt:Cellule T:-:Citometria a flusso
Synonyms: Citometria a flusso (FC) Modelli di superficie cellulare Panel CD154 espressione e funzione Punto nel tempo (episodio) Set di prescrizione per marcatore cellulare
nl-NL Dutch (Netherlands) CD154-expressie & -functie panel:-:moment:T-cellen:-:flowcytometrie
zh-CN Chinese (China) CD154 表达与功能组套:-:时间点:T 细胞:-:流式细胞测量术
Synonyms: CD154 表达与功能组套（组合、医嘱组、套餐、套餐医嘱、医嘱套餐、组合申请、组合项目） FCN T-细胞 动态 医嘱套餐 医嘱套餐类 医嘱套餐组 医嘱组 医嘱组.细胞标志物;组套（组合、医嘱组、套餐、套餐医嘱、医嘱套餐、组合申请、组合项目）类.细胞标志物;实验室医嘱组类.细胞标志物;细胞标志物医嘱组;细胞标志物医嘱组类 医嘱组合 医嘱组合类 医嘱组套 医嘱组套类 医嘱组类 多重;多重型;多重标尺类型;多重精度类型 套餐 套餐医嘱 套餐医嘱组 套餐医嘱组类 实验室医嘱套餐 实验室医嘱套餐类 实验室医嘱组 实验室医嘱组合类 实验室医嘱组套 实验室医嘱组套类 实验室套餐医嘱组 实验室套餐医嘱组类 实验室检验项目医嘱组合类 实验室检验项目组合类 时刻;随机;随意;瞬间 检验医嘱组合类 检验项目医嘱组合类 检验项目组合类 流 流式细胞光度计;流式细胞测量术（Flow Cytometry，FC）;流式细胞计 组 组合 组合医嘱 组合类 组套 细胞标志物

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=98239-7
Questionnaire definition
https://fhir.loinc.org/Questionnaire/?url=http://loinc.org/q/98239-7