41995-2  Hemoglobin A1c [Mass/​volume] in BloodHemoglobin A1c [Mass/​volume] in BloodHemoglobin A1c: MCnc: Pt: Bld: Qn:  

NAME
  Fully Specified Name: 
Component   Property   Time   System   Scale   Method
Hemoglobin A1c  MCnc  Pt  Bld  Qn 
  Long Common Name:  Hemoglobin A1c [Mass/volume] in Blood
  Short Name:  Hgb A1c Bld-mCnc
  Display Name:  HbA1c (Bld) [Mass/Vol]

PART DEFINITION/DESCRIPTION(S)
  Part: Hemoglobin A1c
  Currently (2010), four standardization protocols exist for measuring Hgb A1c:

1. IFCC - designated as a Reference Method or RM (http://www.ifcchba1c.net/)
2. NGSP - the long standing protocol used in the US and most other countries since the DCCT study (http://www.ngsp.org/factors.asp)
3.JDS/JSCC - a protocol used in Japan, Spain and possibly other countries
4. Swedish - used in Sweden at least

Protocols 2-4 are known as Designated Comparison Methods (DCM) and have been connected to the Reference Method and each other through various regression equations.

Because of the high degrees of standardization within protocol it should no longer be necessary to specify a LOINC code with a method such as “HPLC”, “electrophoresis” or anything else. Analytical instruments will be designed so that an Hgb A1c result can be traced back to a specific standardization protocol, so the important distinction will be the standardization protocol as described above and which will be carried in the method field.

A meeting of instrument manufacturers (presumably including Japanese) in Milan, Italy, December 12, 2007, agreed (among other items) that:

-All manufacturers should implement worldwide the traceability to the IFCC reference system for Hgb -A1c.
-All new instruments sold after January 1st, 2011 will report (as a result of an Hgb A1c test) both SI (mmol/mol – no decimals) and NGSP derived units (percentage – one decimal), in agreement with the Consensus Statement.
-Note they only committed to supporting protocol (1) and (2)

Different countries are adopting the international harmonization recommendations in different ways. We have information from the NGSP that the US will continue to report only Hgb A1c/NGSP, with the unit percent – i.e., no change. In Great Britain, labs have already started to report all results both as Hgb A1c (NGSP) in % and Hgb A1c (IFCC) in mmol/mol. In Canada, they are awaiting a recommendation from an expert panel. Any of these measures could be reported in the same units, but the convention for the reporting Hgb A1c under the new IFCC protocol will be to use units of mmol/mol to avoid confusion between the DCCT/NGSP and the IFFCC protocol.

LOINC has defined 59261-8 (Hemoglobin A1c/Hemoglobin.total in Blood) by IFCC protocol.

These protocols produce different results when expressed in the same units. For example, the equivalent of Hgb A1c (NGSP) of 6.5% is Hgb A1c (IFCC) is 4.8%.

The NGSP web site (http://www.ngsp.org/factors.asp) suggests the use of alternate measures, such as glycated albumen, for patients with severe iron deficiency, dialysis patients, and those with SS SC CC because of over or under reading that can occur with these interferences. It also describes the effect of abnormal hemoglobins on results of HbA1c by instrument.
 
 

BASIC ATTRIBUTES
  Class/Type: HEM/BC/Lab
  First Released in Version: 2.16
  Last Updated in Version: 2.34
  Order vs. Obs.: Both
  Status: Active

SUBMITTER'S INFORMATION
  Submitted Units: g/dL

PARTS

Part Type    Part No.  Part Name   
Component   LP16413-4  Hemoglobin A1c 
Property   LP6827-2  MCnc   [Mass Concentration] 
Time   LP6960-1  Pt   [Point in time (spot)] 
System   LP7057-5  Bld   [Blood] 
Scale   LP7753-9  Qn 

LANGUAGE VARIANTS
  Chinese (CHINA)  (From: Regenstrief-generated full translation based on part translation provided by Lin Zhang, A LOINC volunteer from China)
 
  血红蛋白 A1c:质量浓度:时间点:全血:定量型:血红蛋白 A1c:质量浓度:时间点:全血:定量型:
  Dutch (NETHERLANDS)  (From: Regenstrief-generated full translation based on part translation provided by NVKC, Dutch Society for Clinical Chemistry and Laboratory Medicine, The Netherlands)
 
  hemoglobine A1c:massa/​volume:moment:bloed:kwantitatief:hemoglobine A1c:massa/​volume:moment:bloed:kwantitatief:
  Estonian (ESTONIA)  (From: Regenstrief-generated full translation based on part translation provided by Estonian E-Health Foundation)
 
  Hemoglobiin A1c:MCnc:Pt:B:Qn:Hemoglobiin A1c:MCnc:Pt:B:Qn:
  French (BELGIUM)  (From: Regenstrief-generated full translation based on part translation provided by Jean M. Prevost, MD, Biopathology)
 
  Hémoglobine A1c:Concentration de masse:Temps ponctuel:Sang:Quantitatif:Hémoglobine A1c:Concentration de masse:Temps ponctuel:Sang:Quantitatif:
  French (CANADA)  (From: Regenstrief-generated full translation based on part translation provided by Canada Health Infoway Inc.)
 
  Hémoglobine A1c:Concentration de masse:Temps ponctuel:Sang:Quantitatif:Hémoglobine A1c:Concentration de masse:Temps ponctuel:Sang:Quantitatif:
  French (FRANCE)  (From: ASIP Santé (Agence des systèmes d'information partagés de santé))
 
  Hemoglobin A1c:MCnc:Pt:Bld:Qn:Hemoglobin A1c:MCnc:Pt:Bld:Qn:Hémoglobine A1c [Masse/​Volume] Sang ; Numérique
  German (AUSTRIA)  (From: ELGA, Austria)
 
  Hämoglobin A1c
  Greek (GREECE)  (From: Regenstrief-generated full translation based on part translation provided by Efstratia Kontaxi, MD, MSc, and Evripidis Stefanidis, MD, with technical support from Panagiotis Kontaxis, Diploma of Electrical and Computer Engineering.)
 
  Αιμοσφαιρίνη Α1c (γλυκοζυλιωμένη):Συγκέντρωση μάζας:Χρονική στιγμή:Αίμα:Ποσοτική:Αιμοσφαιρίνη Α1c (γλυκοζυλιωμένη):Συγκέντρωση μάζας:Χρονική στιγμή:Αίμα:Ποσοτική:
  Italian (ITALY)  (From: Regenstrief-generated full translation based on part translation provided by Consiglio Nazionale delle Ricerche)
 
  Emoglobina A1c:MCnc:Pt:Sangue:Qn:Emoglobina A1c:MCnc:Pt:Sangue:Qn:
  Korean (KOREA, REPUBLIC OF)  (From: Korean Ministry for Health, Welfare, and Family Affairs)
 
  혈색소 A1C:질량농도:검사시점:전혈:정량:혈색소 A1C:질량농도:검사시점:전혈:정량:
  Portuguese (BRAZIL)  (From: HL7 Brazil Institute)
 
  Hemoglobina A1c:MCnc:Pt:SgTotal:Qn:Hemoglobina A1c:MCnc:Pt:SgTotal:Qn:
  Russian (RUSSIAN FEDERATION)  (From: Regenstrief-generated full translation based on part translation provided by Yaroslavl State Medical Academy)
 
  Гемоглобин А1с:МассКонц:ТчкВрм:Кр:Колич:Гемоглобин А1с:МассКонц:ТчкВрм:Кр:Колич:
  Spanish (SPAIN)  (From: Regenstrief-generated full translation based on part translation provided by the Clinical Laboratory Committee of SERVICIO EXTREMEÑO DE SALUD, with the support of BITAC MAP.)
 
  Hemoglobina A1c (Hemoglobina glicosilada):Concentración de masa:Punto temporal:Sangre:Qn:Hemoglobina A1c (Hemoglobina glicosilada):Concentración de masa:Punto temporal:Sangre:Qn:
  Turkish (TURKEY)  (From: Regenstrief-generated full translation based on part translation provided by LOINC Turkish Translation Group and the Turkish Ministry of Health)
 
  Hemoglobin A1c:KütlKons:Zmlı:Kan:Kant:Hemoglobin A1c:KütlKons:Zmlı:Kan:Kant:

RELATED NAMES
  Blood Hb QNT
  GHb HbA1c Quan
  Glycated hemoglobin HEMATOLOGY/CELL COUNTS Quant
  Glycohaemogolobin Hgb Quantitative
  Glycohemogolobin Hgb A1c Random
  Glycosylated hemoglobin Level WB
  HA1c Mass concentration Whole blood
  Haemoglobin Point in time  

EXAMPLE UNITS
  Unit  Source Type
  g/dL  EXAMPLE UCUM UNITS 
  g/dL  ORIGINAL SUBMISSION 

UNITS (INTERNAL DETAILS)
  Source Type:  EXAMPLE UCUM UNITS 
  Unit:  g/dL 
  Source Type:  ORIGINAL SUBMISSION 
  Unit:  g/dL 

CHANGE HISTORY
  Change Type: MIN

INTERNAL FIELDS
  Detail Page Created On: 6/26/2019 5:48:56 PM
  Attachment Units Required: N
  Long Common Name: Hemoglobin A1c [Mass/volume] in Blood
  Shortname: Hgb A1c Bld-mCnc
  Fully Specified Name: Hemoglobin A1c: MCnc: Pt: Bld: Qn:
     
  Component Word Count: 2
  ID: 33369
  Status (Raw): ACTIVE