44645-0  Nuclear pleomorphism in Breast tumor Qualitative by NottinghamNuclear pleomorphism in Breast tumor Qualitative by NottinghamNuclear pleomorphism: Score: Pt: Breast tumor: Ord: Nottingham  

NAME
  Fully-Specified Name: 
Component   Property   Time   System   Scale   Method
Nuclear pleomorphism  Score  Pt  Breast tumor  Ord  Nottingham
  Long Common Name:  Nuclear pleomorphism in Breast tumor Qualitative by Nottingham
  Shortname:  Nuc pleomorph BT Nottingham
  DisplayName:  Nuclear pleomorphism Nottingham Ql (Breast tumor)

PART DEFINITION/DESCRIPTION(S)
  Part: Nuclear pleomorphism
  The degree of nuclear pleomorphism (variability of nuclei) in breast carcinoma is one component of the Nottingham histologic grade (NHG) [LOINC: 44648-4] , which is a prognostic indicator for patients with breast carcinoma. The two other components of the NHG are tubule formation [LOINC: 85321-8] and mitotic activity [LOINC: 85300-2] . Increasing degrees of pleomorphism are associated with increasingly aggressive cancers, with scores assigned as follows:
1 = no pleomorphism
2 = moderate pleomorphism
3 = extensive pleomorphism
[PMID: 11865000]
 
 

BASIC ATTRIBUTES
  Class/Type: PATH.PROTOCOLS.BRST/Lab
  First Released in Version: 2.17
  Last Updated in Version: 2.61
  Order vs. Obs.: Observation
  Status: Active.
Change Reason: Removed Method of CAP because this concept is part of the Nottingham histologic score, and added Method of Nottingham. Also updated Property from Arb to Score and added Normative answer list.

NORMATIVE ANSWER LIST    (LL4382-9)  
 
Source: College of American Pathologists
  SEQ#        Answer        Score        Answer ID    
  1       Nuclei small with little increase in size in comparison with normal outlines, uniform clear chromatin, little variation in size       1       LA27222-1  
  2       Cells larger than normal with open vesicular nuclei, visible nucleo size and shape       2       LA27223-9  
  3       Vesicular nuclei, often with prominent nucleoli, exhibited marked occasionally with very large and bizzare forms       3       LA27224-7  
  4       Only microinvasion present (not graded)       0       LA27219-7  
  5       No residual invasive carcinoma after presurgical (neoadjuvant) therapy       0       LA27220-5  
  6       Score cannot be determined       0       LA27221-3  

MEMBER OF THESE PANELS
  85904-1   Cancer pathology panel - Breast cancer specimen by CAP cancer protocolsCancer pathology panel - Breast cancer specimen by CAP cancer protocolsCancer pathology panel: -: Pt: Breast cancer specimen: -: CAP cancer protocols

PARTS

Part Type    Part No.  Part Name   
Component   LP72992-8  Nuclear pleomorphism 
Property   LP185820-0  Score 
Time   LP6960-1  Pt   [Point in time (spot)] 
System   LP36755-4  Breast tumor 
Scale   LP7751-3  Ord 
Method   LP248063-2  Nottingham 

LANGUAGE VARIANTS
  Chinese (CHINA)  (From: Regenstrief-generated full translation based on part translation provided by Lin Zhang, A LOINC volunteer from China)
 
  核多形性:评分:时间点:乳腺肿瘤:序数型:诺丁汉法核多形性:评分:时间点:乳腺肿瘤:序数型:诺丁汉法
  Italian (ITALY)  (From: Regenstrief-generated full translation based on part translation provided by Consiglio Nazionale delle Ricerche)
 
  Pleomorfismo nucleare:Punteggio:Pt:Tumore della mammella:Ord:NottinghamPleomorfismo nucleare:Punteggio:Pt:Tumore della mammella:Ord:Nottingham
  Portuguese (BRAZIL)  (From: HL7 Brazil Institute)
 
  Pleomorfismo nuclear:Arb:Pt:Tumor mamário:Ord:Protocolos de cancer do CAPPleomorfismo nuclear:Arb:Pt:Tumor mamário:Ord:Protocolos de cancer do CAP
  Spanish (SPAIN)  (From: Regenstrief-generated full translation based on part translation provided by the Clinical Laboratory Committee of SERVICIO EXTREMEÑO DE SALUD, with the support of BITAC MAP.)
 
  Pleomorfismo nuclear:Puntuación:Punto temporal:Tumor de mama:Ord:NottinghamPleomorfismo nuclear:Puntuación:Punto temporal:Tumor de mama:Ord:Nottingham

RELATED NAMES
  Brst PATHOLOGY PROTOCOLS Scale
  BT PATHOLOGY PROTOCOLS BREAST Screen
  Cancer Point in time tumors
  Nuc QL tumour
  Nuc pleomorph Qual tumours
  Ordinal Qualitative  
  Pathology Random  

CHANGE HISTORY
  Change Type: MAJ

INTERNAL FIELDS
  Detail Page Created On: 9/27/2018 5:44:03 AM
  Attachment Units Required: N
  Long Common Name: Nuclear pleomorphism in Breast tumor Qualitative by Nottingham
  Shortname: Nuc pleomorph BT Nottingham
  Fully Specified Name: Nuclear pleomorphism: Score: Pt: Breast tumor: Ord: Nottingham
     
  Component Word Count: 2
  ID: 37886
  Status (Raw): ACTIVE