44648-4  Histologic grade [Score] in Breast cancer specimen Qualitative by NottinghamHistologic grade [Score] in Breast cancer specimen Qualitative by NottinghamHistologic grade: Score: Pt: Breast cancer specimen: Ord: Nottingham  

NAME
  Fully-Specified Name: 
Component   Property   Time   System   Scale   Method
Histologic grade  Score  Pt  Breast cancer specimen  Ord  Nottingham
  Long Common Name:  Histologic grade [Score] in Breast cancer specimen Qualitative by Nottingham
  Shortname:  Histo grade Br ca spec Ql Nottingham
  DisplayName:  Histologic grade Nottingham Ql (Breast cancer specimen)

TERM DEFINITION/DESCRIPTION(S)
  Nottingham histologic grade (NHG) is a prognostic indicator for patients with breast carcinoma. The NHG is based on a combination of individual scores for the degree of tubule formation [LOINC: 85321-8] , nuclear pleomorphism [LOINC: 44645-0] , and mitotic activity [LOINC: 85300-2] . Each parameter is given a score from 1 to 3, and the final NGH grade is determined based on the sum of those three scores. Grade 1 is assigned for a summed score of 3, 4 or 5; grade 2 is assigned for a summed score of 6 or 7; and grade 3 is assigned for a summed score of 8 or 9. A higher grade is associated with a more aggressive cancer, and patients with grade 3 carcinoma tend to have lower long-term survival rates compared to patients with grade 1. The individual tubule formation and mitotic activity scores may also be independent predictors of survival. [PMID: 11865000]
 
 

BASIC ATTRIBUTES
  Class/Type: PATH.HISTO/Lab
  First Released in Version: 2.17
  Last Updated in Version: 2.61
  Order vs. Obs.: Observation
  Status: Active.
Change Reason: Removed CAP Copyright and Method because this concept is not specific to CAP, moved Nottingham from Component to Method, changed System from "Breast tumor" because the concept is specific to breast cancer, added answer list.

NORMATIVE ANSWER LIST    (LL4561-8)  
 
Source: College of American Pathologists
  SEQ#        Answer        Answer ID    
  1       Nottingham grade 1
Description: Scores of 3, 4 or 5
  LA27823-6  
  2       Nottingham grade 2
Description: Scores of 6 or 7
  LA27824-4  
  3       Nottingham grade 3
Description: Scores of 8 or 9
  LA27825-1  
  4       Only microinvasion present (not graded)       LA27219-7  
  5       No residual invasive carcinoma after presurgical (neoadjuvant) therapy       LA27220-5  
  6       Score cannot be determined       LA27221-3  

MEMBER OF THESE PANELS
  85904-1   Cancer pathology panel - Breast cancer specimen by CAP cancer protocolsCancer pathology panel - Breast cancer specimen by CAP cancer protocolsCancer pathology panel: -: Pt: Breast cancer specimen: -: CAP cancer protocols

PARTS

Part Type    Part No.  Part Name   
Component   LP94898-1  Histologic grade 
Property   LP185820-0  Score 
Time   LP6960-1  Pt   [Point in time (spot)] 
System   LP247851-1  Breast cancer specimen 
Scale   LP7751-3  Ord 
Method   LP248063-2  Nottingham 

LANGUAGE VARIANTS
  Chinese (CHINA)  (From: Regenstrief-generated full translation based on part translation provided by Lin Zhang, A LOINC volunteer from China)
 
  组织学分级:评分:时间点:乳腺癌标本:序数型:诺丁汉法组织学分级:评分:时间点:乳腺癌标本:序数型:诺丁汉法
  Italian (ITALY)  (From: Regenstrief-generated full translation based on part translation provided by Consiglio Nazionale delle Ricerche)
 
  Grado istologico:Punteggio:Pt:Tumore della mammella, campione:Ord:NottinghamGrado istologico:Punteggio:Pt:Tumore della mammella, campione:Ord:Nottingham
  Spanish (SPAIN)  (From: Regenstrief-generated full translation based on part translation provided by the Clinical Laboratory Committee of SERVICIO EXTREMEÑO DE SALUD, with the support of BITAC MAP.)
 
  Grado histológico:Puntuación:Punto temporal:Muestra de cancer de mama:Ord:NottinghamGrado histológico:Puntuación:Punto temporal:Muestra de cancer de mama:Ord:Nottingham

RELATED NAMES
  Br ca spec PATH.HISTO Random
  Brst PATHOLOGY Scale
  CA Point in time Screen
  Ca spec QL Spec
  Histo grade Qual  
  Ordinal Qualitative  

EXAMPLE UNITS
  Unit  Source Type
  {score}  EXAMPLE UCUM UNITS 

UNITS (INTERNAL DETAILS)
  Source Type:  EXAMPLE UCUM UNITS 
  Unit:  {score} 

CHANGE HISTORY
  Change Type: MIN

INTERNAL FIELDS
  Detail Page Created On: 9/27/2018 5:44:03 AM
  Attachment Units Required: N
  Long Common Name: Histologic grade [Score] in Breast cancer specimen Qualitative by Nottingham
  Shortname: Histo grade Br ca spec Ql Nottingham
  Fully Specified Name: Histologic grade: Score: Pt: Breast cancer specimen: Ord: Nottingham
     
  Component Word Count: 2
  ID: 37889
  Status (Raw): ACTIVE