49683-6  HER2/​CEP17 [Ratio] in Tissue by FISHHER2/​CEP17 [Ratio] in Tissue by FISHHER2/​CEP17: Ratio: Pt: Tiss: Qn: FISH  

NAME
  Fully-Specified Name: 
Component   Property   Time   System   Scale   Method
HER2/CEP17  Ratio  Pt  Tiss  Qn  FISH
  Long Common Name:  HER2/CEP17 [Ratio] in Tissue by FISH
  Shortname:  Her2/CEP17 Tiss FISH-Rto
  DisplayName:  HER2/CEP17 FISH Ratio (Tiss)

TERM DEFINITION/DESCRIPTION(S)
  The ratio of HER-2/neu to CEP17 probes by in situ hybridization assays (e.g. FISH) to determine overexpression of HER-2/neu protein in breast cancer. CEP17 is used as an internal control and to account for aneusomy (varying number) of chromosome 17. A ratio of >2.0 indicates gene amplification and overexpression of HER-2/neu according to the 2013 ASCO-CAP HER2 test guideline recommendations. Results are used to assist in dose selection for certain drugs, assess eligibility for trastuzumab (Herceptin®) treatment, predict response to drug therapies and overall survival in patients with breast cancer. For testing without an internal control probe, see LOINCs 31150-6 and 48675-3. For determining HER-2 status by Immunohistochemistry (IHC), see LOINC 18474-7.
 
 

PART DEFINITION/DESCRIPTION(S)
  Part: HER2
  HER2/neu (also known as ErbB-2) stands for "Human Epidermal growth factor Receptor 2" and is a protein giving higher aggressiveness in breast cancers. It is a member of the ErbB protein family, more commonly known as the epidermal growth factor receptor family. HER2/neu has also been designated as CD340 (cluster of differentiation 340) and p185. It is encoded by the ERBB2 gene.
  Copyright: Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details.
 
 
  Part: FISH
  FISH (fluorescence in situ hybridization) is a cytogenetic technique used to detect and localize the presence or absence of specific DNA sequences on chromosomes. FISH uses fluorescent probes that bind to only those parts of the chromosome with which they show a high degree of sequence similarity. Fluorescence microscopy can be used to find out where the fluorescent probe bound to the chromosomes. FISH is often used for finding specific features in DNA for use in genetic counseling, medicine, and species identification. FISH can also be used to detect and localize specific mRNAs within tissue samples. In this context, it can help define the spatial-temporal patterns of gene expression within cells and tissues.
  Copyright: Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details.
 
 

BASIC ATTRIBUTES
  Class/Type: MOLPATH/Lab
  First Released in Version: 2.22
  Last Updated in Version: 2.61
  Order vs. Obs.: Both
  Status: Active

EXAMPLE ANSWERS
  0-100

MEMBER OF THESE PANELS
  74885-5   HER2 panel - Tissue by FISHHER2 panel - Tissue by FISHHER2 panel: -: Pt: Tiss: -: FISH
  85904-1   Cancer pathology panel - Breast cancer specimen by CAP cancer protocolsCancer pathology panel - Breast cancer specimen by CAP cancer protocolsCancer pathology panel: -: Pt: Breast cancer specimen: -: CAP cancer protocols

PARTS

Part Type    Part No.  Part Name   
Component   LP28442-9  HER2 
     Quotients   LP64927-4  HER2/CEP17 
     Divisors   LP70342-8  CEP17 
Property   LP6852-0  Ratio 
Time   LP6960-1  Pt   [Point in time (spot)] 
System   LP7641-6  Tiss   [Tissue and Smears] 
Scale   LP7753-9  Qn 
Method   LP62864-1  FISH   [Fluorescent in situ hybridization (FISH)] 
Fragments for synonyms   LP111483-6  CEP17 

LANGUAGE VARIANTS
  Chinese (CHINA)  (From: Regenstrief-generated full translation based on part translation provided by Lin Zhang, A LOINC volunteer from China)
 
  Her2/​CEP17:比率:时间点:组织与涂片:定量型:FISHHer2/​CEP17:比率:时间点:组织与涂片:定量型:FISH
  Dutch (NETHERLANDS)  (From: Regenstrief-generated full translation based on part translation provided by NVKC, Dutch Society for Clinical Chemistry and Laboratory Medicine, The Netherlands)
 
  HER2/​CEP17:verhouding:moment:weefsel en uitstrijkjes:kwantitatief:FISHHER2/​CEP17:verhouding:moment:weefsel en uitstrijkjes:kwantitatief:FISH
  Estonian (ESTONIA)  (From: Regenstrief-generated full translation based on part translation provided by Estonian E-Health Foundation)
 
  HER2/​CEP17:Suhe:Pt:Tis:Qn:FISHHER2/​CEP17:Suhe:Pt:Tis:Qn:FISH
  French (BELGIUM)  (From: Regenstrief-generated full translation based on part translation provided by Jean M. Prevost, MD, Biopathology)
 
  HER2/​CEP17:Ratios:Temps ponctuel:Tissu:Quantitatif:Hybridation fluorescente in situHER2/​CEP17:Ratios:Temps ponctuel:Tissu:Quantitatif:Hybridation fluorescente in situ
  French (CANADA)  (From: Regenstrief-generated full translation based on part translation provided by Canada Health Infoway Inc.)
 
  HER2/​CEP17:Ratios:Temps ponctuel:Tissu:Quantitatif:Hybridation fluorescente in situHER2/​CEP17:Ratios:Temps ponctuel:Tissu:Quantitatif:Hybridation fluorescente in situ
  French (FRANCE)  (From: ASIP Santé (Agence des systèmes d'information partagés de santé))
 
  HER2/​CEP17:Ratio:Ponctuel:Tissu:Numérique:FISHHER2/​CEP17:Ratio:Ponctuel:Tissu:Numérique:FISHHER2/​CEP17 [Ratio] Tissu ; Numérique ; FISH
  Italian (ITALY)  (From: Regenstrief-generated full translation based on part translation provided by Consiglio Nazionale delle Ricerche)
 
  HER2/​CEP17:Rapporto:Pt:Tessuto:Qn:FISHHER2/​CEP17:Rapporto:Pt:Tessuto:Qn:FISH
  Portuguese (BRAZIL)  (From: HL7 Brazil Institute)
 
  HER2/​CEP17:Ratio:Pt:Tecido:Qn:FISH (hibridização in situ fluorescente)HER2/​CEP17:Ratio:Pt:Tecido:Qn:FISH (hibridização in situ fluorescente)
  Spanish (SPAIN)  (From: Regenstrief-generated full translation based on part translation provided by the Clinical Laboratory Committee of SERVICIO EXTREMEÑO DE SALUD, with the support of BITAC MAP.)
 
  Factor de crecimiento epidérmico humano tipo 2/​CEP17:Fracción:Punto temporal:Tejido:Qn:Hibridación in situ fluoresente (FISH)Factor de crecimiento epidérmico humano tipo 2/​CEP17:Fracción:Punto temporal:Tejido:Qn:Hibridación in situ fluoresente (FISH)
  Turkish (TURKEY)  (From: Regenstrief-generated full translation based on part translation provided by LOINC Turkish Translation Group and the Turkish Ministry of Health)
 
  HER2/​CEP17:Oran:Zmlı:Doku:Kant:FISHHER2/​CEP17:Oran:Zmlı:Doku:Kant:FISH

RELATED NAMES
  C-ERBB-2 HER-2/neu Random
  Chromosome 17 centromere Molecular pathology Ratios
  erb MOLPATH Rto
  ERB2 Point in time Tissue
  ERB-2 QNT Tissue, unspecified
  erbB2 Quan  
  Fluorescent in situ hybridization Quant  
  HER-2 Quantitative  

CHANGE HISTORY
  Change Type: MIN

INTERNAL FIELDS
  Detail Page Created On: 9/27/2018 4:15:15 AM
  Attachment Units Required: N
  Long Common Name: HER2/CEP17 [Ratio] in Tissue by FISH
  Shortname: Her2/CEP17 Tiss FISH-Rto
  Fully Specified Name: HER2/CEP17: Ratio: Pt: Tiss: Qn: FISH
     
  Component Word Count: 2
  ID: 43447
  Status (Raw): ACTIVE