50956-2  HLA-B*57:01 [Presence]HLA-B*57:01 [Presence]HLA-B*57:01: PrThr: Pt: Bld/​Tiss: Ord:  

NAME
  Fully-Specified Name: 
Component   Property   Time   System   Scale   Method
HLA-B*57:01  PrThr  Pt  Bld/Tiss  Ord 
  Long Common Name:  HLA-B*57:01 [Presence]
  Shortname:  HLA-B*57:01 Ql

PART DEFINITION/DESCRIPTION(S)
  Part: HLA-B*57:01
  Part of HLA-B57 allele family that is associated with Abacavir hypersensitivity reaction (AHSR)
 
 
  Part: HLA-B*57:01
  The human leukocyte antigen B (HLA-B) plays an important role in how the immune system recognizes and responds to pathogens. HLA-B belongs to a class of molecules that are found on the surface of most cells. These molecules are responsible for presenting peptides to immune cells. Peptides derived from normal human proteins are recognized as such, whereas foreign peptides derived from pathogens trigger an immune response. The antiretroviral medication abacavir specifically interacts with HLA-B*57:01 and alters the repertoire of self-peptides that are presented to T lymphocytes, which activates an immune reaction known as a hypersensitivity reaction. [PMID: 24561393] See https://www.pharmgkb.org/gene/PA35056 for more information and dosing guidelines for drugs impacted by HLA-B genetic variation.
 
 

BASIC ATTRIBUTES
  Class/Type: HLA/Lab
  First Released in Version: 2.22
  Last Updated in Version: 2.56
  Order vs. Obs.: Both
  Status: Active.
Change Reason: This test is commonly performed on cells found in saliva and buccal swabs as well as blood specimens. Changed specimen from 'Bld' to 'Bld/Tiss' to represent both specimen types.; The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.

PREFERRED ANSWER LIST    (LL360-9)  
  SEQ#        Answer        Answer ID    
  1       Positive       LA6576-8  
  2       Negative       LA6577-6  

PARTS

Part Type    Part No.  Part Name   
Component   LP36049-2  HLA-B*57:01 
Property   LP217195-9  PrThr   [Presence or Threshold] 
Time   LP6960-1  Pt   [Point in time (spot)] 
System   LP7061-7  Bld/Tiss   [Blood or Tissue] 
Scale   LP7751-3  Ord 
Fragments for synonyms   LP57611-3  HLA 

LANGUAGE VARIANTS
  Chinese (CHINA)  (From: Regenstrief-generated full translation based on part translation provided by Bethune International Peace Hospital)
 
  HLA-B*57:01:  存在情况或阈值:  时间点:  全血/​组织:  序数型:  HLA-B*57:01:  存在情况或阈值:  时间点:  全血/​组织:  序数型:  HLA-B*57:01:  存在情况或阈值:  时间点:  全血/​组织:  序数型:  
  Dutch (NETHERLANDS)  (From: Regenstrief-generated full translation based on part translation provided by NVKC, Dutch Society for Clinical Chemistry and Laboratory Medicine, The Netherlands)
 
  HLA-B*5701:  PrThr:  Moment:  Bloed/​Weefsel:  Ordinaal:  HLA-B*5701:  PrThr:  Moment:  Bloed/​Weefsel:  Ordinaal:  HLA-B*5701:  PrThr:  Moment:  Bloed/​Weefsel:  Ordinaal:  
  Estonian (ESTONIA)  (From: Regenstrief-generated full translation based on part translation provided by Estonian E-Health Foundation)
 
  HLA-B5701:  PrThr:  Pt:  B/​Tis:  Ord:  HLA-B5701:  PrThr:  Pt:  B/​Tis:  Ord:  HLA-B5701:  PrThr:  Pt:  B/​Tis:  Ord:  
  French (BELGIUM)  (From: Regenstrief-generated full translation based on part translation provided by Jean M. Prevost, MD, Biopathology)
 
  HLA-B5701:  PrThr:  Temps ponctuel:  Sang/​Tissu:  Ordinal:  HLA-B5701:  PrThr:  Temps ponctuel:  Sang/​Tissu:  Ordinal:  HLA-B5701:  PrThr:  Temps ponctuel:  Sang/​Tissu:  Ordinal:  
  French (CANADA)  (From: Regenstrief-generated full translation based on part translation provided by Canada Health Infoway Inc.)
 
  HLA-B*57:01:  Présence-Seuil:  Temps ponctuel:  Sang/​Tissu:  Ordinal:  HLA-B*57:01:  Présence-Seuil:  Temps ponctuel:  Sang/​Tissu:  Ordinal:  HLA-B*57:01:  Présence-Seuil:  Temps ponctuel:  Sang/​Tissu:  Ordinal:  
  French (FRANCE)  (From: ASIP Santé (Agence des systèmes d'information partagés de santé))
 
  HLA-B*5701:  Arbitraire/​Volume:  Ponctuel:  Sang/​Tissu:  Qualitatif:  HLA-B*5701:  Arbitraire/​Volume:  Ponctuel:  Sang/​Tissu:  Qualitatif:  HLA-B*5701:  Arbitraire/​Volume:  Ponctuel:  Sang/​Tissu:  Qualitatif:  
  Italian (ITALY)  (From: Regenstrief-generated full translation based on part translation provided by Consiglio Nazionale delle Ricerche)
 
  HLA-B*57:01:  PrThr:  Pt:  Sangue/​Tess:  Ord:  HLA-B*57:01:  PrThr:  Pt:  Sangue/​Tess:  Ord:  HLA-B*57:01:  PrThr:  Pt:  Sangue/​Tess:  Ord:  
  Portuguese (BRAZIL)  (From: HL7 Brazil Institute)
 
  HLA-B5701 QlHLA-B5701:  ACnc:  Pt:  SgTotal:  Ord:  HLA-B5701:  ACnc:  Pt:  SgTotal:  Ord:  
  Russian (RUSSIAN FEDERATION)  (From: Regenstrief-generated full translation based on part translation provided by Yaroslavl State Medical Academy)
 
  HLA-B*5701:  PrThr:  ТчкВрм:  Кр/​Тк:  Пор:  HLA-B*5701:  PrThr:  ТчкВрм:  Кр/​Тк:  Пор:  HLA-B*5701:  PrThr:  ТчкВрм:  Кр/​Тк:  Пор:  
  Spanish (SPAIN)  (From: Regenstrief-generated full translation based on part translation provided by the Clinical Laboratory Committee of SERVICIO EXTREMEÑO DE SALUD, with the support of BITAC MAP.)
 
  HLA-B*57:01:  Propiedad utilizada para términos LOINC cuyos resultados estan en escala categórica ordenada.:  Punto temporal:  Sangre o tejido:  Ord:  HLA-B*57:01:  Propiedad utilizada para términos LOINC cuyos resultados estan en escala categórica ordenada.:  Punto temporal:  Sangre o tejido:  Ord:  HLA-B*57:01:  Propiedad utilizada para términos LOINC cuyos resultados estan en escala categórica ordenada.:  Punto temporal:  Sangre o tejido:  Ord:  
  Turkish (TURKEY)  (From: Regenstrief-generated full translation based on part translation provided by LOINC Turkish Translation Group and the Turkish Ministry of Health)
 
  HLA-B*5701:  MevcEşik:  Zmlı:  Kan/​Dk:  Srl:  HLA-B*5701:  MevcEşik:  Zmlı:  Kan/​Dk:  Srl:  HLA-B*5701:  MevcEşik:  Zmlı:  Kan/​Dk:  Srl:  

RELATED NAMES
  Abacavir hypersensititvity Ordinal Screen
  Blood Point in time Tissue
  HLA ANTIGEN PR Tissue, unspecified
  HLA-B57 QL WB
  HLA-B57*01 Qual Whole blood
  HLA-B5701 Qualitative Whole blood or Tissue
  Human Leukocyte Antigen Random  

CHANGE HISTORY
  Change Type: MIN

INTERNAL FIELDS
  Attachment Units Required: N
  Long Common Name: HLA-B*57:01 [Presence]
  Shortname: HLA-B*57:01 Ql
  Fully Specified Name: HLA-B*57:01: PrThr: Pt: Bld/Tiss: Ord:
     
  Component Word Count: 2
  ID: 44862
  Status (Raw): ACTIVE