74860-8  HER2 signals/​nucleus [Entitic number] in Tissue by FISHHER2 signals/​nucleus [Entitic number] in Tissue by FISHHER2 signals/​nucleus: EntNum: Pt: Tiss: Qn: FISH  

NAME
  Fully-Specified Name: 
Component   Property   Time   System   Scale   Method
HER2 signals/nucleus  EntNum  Pt  Tiss  Qn  FISH
  Long Common Name:  HER2 signals/nucleus [Entitic number] in Tissue by FISH
  Shortname:  HER2 Sig/nucleus EntNum Tiss FISH
  DisplayName:  HER2 signals/nucleus FISH Entitic number (Tiss)

TERM DEFINITION/DESCRIPTION(S)
  The average number of HER2 fluorescent signals in nuclei are determined in order to calculate the average ratio of HER2 to CEP17 signals [LOINC: 49683-6] . This term is based on, but not limited in use to, the PathVysion HER-2 DNA Probe Kit, which detects amplification of the ERBB2 gene (HER2 locus) via fluorescence in situ hybridization (FISH) in formalin-fixed, paraffin-embedded human breast and gastric cancer tissue specimens. The kit contains two probes: one specific to the HER-2/neu gene locus (ERBB2 gene, 17q11.2-q12) and another targeting the alpha satellite DNA sequence at the centromeric region of chromosome 17 (17p11.1-q11.1), called CEP17 (Chromosome Enumeration Probe 17). The average number of HER2 signals along with CEP17 signals [LOINC: 74861-6] are determined by microscopic examination within the same set of nuclei. The specimen is positive for ERBB2 gene amplification if the mean ratio of HER2 to CEP17 signals per nucleus is greater than or equal to 2.00.
 
 

PART DEFINITION/DESCRIPTION(S)
  Part: HER2 signals
  HER2/neu (also known as ErbB-2) stands for "Human Epidermal growth factor Receptor 2" and is a protein giving higher aggressiveness in breast cancers. It is a member of the ErbB protein family, more commonly known as the epidermal growth factor receptor family. HER2/neu has also been designated as CD340 (cluster of differentiation 340) and p185. It is encoded by the ERBB2 gene.
  Copyright: Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details.
 
 
  Part: FISH
  FISH (fluorescence in situ hybridization) is a cytogenetic technique used to detect and localize the presence or absence of specific DNA sequences on chromosomes. FISH uses fluorescent probes that bind to only those parts of the chromosome with which they show a high degree of sequence similarity. Fluorescence microscopy can be used to find out where the fluorescent probe bound to the chromosomes. FISH is often used for finding specific features in DNA for use in genetic counseling, medicine, and species identification. FISH can also be used to detect and localize specific mRNAs within tissue samples. In this context, it can help define the spatial-temporal patterns of gene expression within cells and tissues.
  Copyright: Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details.
 
 

BASIC ATTRIBUTES
  Class/Type: MOLPATH/Lab
  First Released in Version: 2.48
  Last Updated in Version: 2.61
  Order vs. Obs.: Observation
  Status: Active

MEMBER OF THESE PANELS
  74885-5   HER2 panel - Tissue by FISHHER2 panel - Tissue by FISHHER2 panel: -: Pt: Tiss: -: FISH
  85904-1   Cancer pathology panel - Breast cancer specimen by CAP cancer protocolsCancer pathology panel - Breast cancer specimen by CAP cancer protocolsCancer pathology panel: -: Pt: Breast cancer specimen: -: CAP cancer protocols

PARTS

Part Type    Part No.  Part Name   
Component   LP182376-6  HER2 signals 
     Divisors   LP182349-3  nucleus 
Property   LP6806-6  EntNum   [Entitic number] 
Time   LP6960-1  Pt   [Point in time (spot)] 
System   LP7641-6  Tiss   [Tissue and Smears] 
Scale   LP7753-9  Qn 
Method   LP62864-1  FISH   [Fluorescent in situ hybridization (FISH)] 

LANGUAGE VARIANTS
  Chinese (CHINA)  (From: Regenstrief-generated full translation based on part translation provided by Lin Zhang, A LOINC volunteer from China)
 
  HER2 信号/​核:实体数量:时间点:组织与涂片:定量型:FISHHER2 信号/​核:实体数量:时间点:组织与涂片:定量型:FISH
  Dutch (NETHERLANDS)  (From: Regenstrief-generated full translation based on part translation provided by NVKC, Dutch Society for Clinical Chemistry and Laboratory Medicine, The Netherlands)
 
  HER2 signalen/​kern:aantal/​eenheid:moment:weefsel en uitstrijkjes:kwantitatief:FISHHER2 signalen/​kern:aantal/​eenheid:moment:weefsel en uitstrijkjes:kwantitatief:FISH
  French (FRANCE)  (From: ASIP Santé (Agence des systèmes d'information partagés de santé))
 
  HER2 signaux/​noyaux:Numération d'entité:Ponctuel:Tissu:Numérique:FISHHER2 signaux/​noyaux:Numération d'entité:Ponctuel:Tissu:Numérique:FISHHER2 signaux/​noyaux [Numération d'entité] Tissu ; Numérique ; FISH
  Italian (ITALY)  (From: Regenstrief-generated full translation based on part translation provided by Consiglio Nazionale delle Ricerche)
 
  HER2, segnali/​, nucleo:EntNum:Pt:Tessuto:Qn:FISHHER2, segnali/​, nucleo:EntNum:Pt:Tessuto:Qn:FISH
  Portuguese (BRAZIL)  (From: HL7 Brazil Institute)
 
  HER2 sinais/​núcleo::Pt:Tecido:Qn:FISHHER2 sinais/​núcleo::Pt:Tecido:Qn:FISH
  Spanish (SPAIN)  (From: Regenstrief-generated full translation based on part translation provided by the Clinical Laboratory Committee of SERVICIO EXTREMEÑO DE SALUD, with the support of BITAC MAP.)
 
  Señales HER2/​núcleo:Número entítico:Punto temporal:Tejido:Qn:Hibridación in situ fluoresente (FISH)Señales HER2/​núcleo:Número entítico:Punto temporal:Tejido:Qn:Hibridación in situ fluoresente (FISH)
  Turkish (TURKEY)  (From: Regenstrief-generated full translation based on part translation provided by LOINC Turkish Translation Group and the Turkish Ministry of Health)
 
  HER2 sinyallaeri/​çekirdek:EntSay:Zmlı:Doku:Kant:FISHHER2 sinyallaeri/​çekirdek:EntSay:Zmlı:Doku:Kant:FISH

RELATED NAMES
  breast cancer ErbB-2 QNT
  CD340 Fluorescent in situ hybridization Quan
  C-ERBB-2 HER-2 Quant
  Entitic HER2/neu Quantitative
  Entitic number HER-2/neu Random
  erb Molecular pathology Tissue
  ERB2 MOLPATH Tissue, unspecified
  ERB-2 p185  
  erbB2 Point in time  

EXAMPLE UNITS
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  {#}  EXAMPLE UCUM UNITS 

UNITS (INTERNAL DETAILS)
  Source Type:  EXAMPLE UCUM UNITS 
  Unit:  {#} 

CHANGE HISTORY
  Change Type: MIN

INTERNAL FIELDS
  Detail Page Created On: 9/26/2018 8:27:09 PM
  Long Common Name: HER2 signals/nucleus [Entitic number] in Tissue by FISH
  Shortname: HER2 Sig/nucleus EntNum Tiss FISH
  Fully Specified Name: HER2 signals/nucleus: EntNum: Pt: Tiss: Qn: FISH
     
  Component Word Count: 3
  ID: 76515
  Status (Raw): ACTIVE