92736-8  CD3+​CD4+​ (T4 helper) cells [#/​volume] in Blood by Rapid immunoassayCD3+​CD4+​ (T4 helper) cells [#/​volume] in Blood by Rapid immunoassayCells.CD3+​CD4+​: NCnc: Pt: Bld: Qn: IA.rapid  

NAME
  Fully Specified Name: 
Component   Property   Time   System   Scale   Method
Cells.CD3+CD4+  NCnc  Pt  Bld  Qn  IA.rapid
  Long Common Name:  CD3+CD4+ (T4 helper) cells [#/volume] in Blood by Rapid immunoassay
  Short Name:  CD3+CD4+ Cells # Bld IA.rapid
  Display Name:  CD3+CD4+ (T4 helper) cells IA.rapid (Bld) [#/Vol]

TERM DEFINITION/DESCRIPTION(S)
  CD4+ count based on immunoassay method that utilizes anti-CD3 and anti-CD4 antibodies to detect CD4+ cells. This term was created for, but is not limited in use to, the submitter's Alere Pima CD4 test, which is intended for the rapid measurement of CD4+ T-helper cells and produces results in 20 minutes.
 
 

PART DEFINITION/DESCRIPTION(S)
  Part: Cells.CD3+CD4+
  HIV infection decreases the number of CD4 T-cells, also called T4 helper cells, the ratio of CD4 to CD8 T-cells and the number of CD8+ T-cells. These counts are ordered frequently to guide decisions about anti-retroviral therapy. Laboratories usually report both percentage and absolute count. When you map CD4 and CD8 markers, be careful! Since at least 1997, CDC has required the detection of both CD3+ and CD4+ to identify T4 helper cells, because the CD3 marker is needed to identify T-cell . So, any tests that report T4 helper cells are really reporting cells that carry BOTH the CD3+ and the CD4+ markers. The measure name may be CD3+ CD4+ cells, CD4+ marker, T4 cells or even just CD4+ (a misnomer). Exactly analogous rules apply to CD8+. Measures that include only CD4 or only CD8 in their name are really measuring CD3+CD4+ cells or CD3+CD8+ cells, respectively and should be reported with the LOINC code that includes both of those markers. The panel named T cell subsets will usually contain both CD3 + CD4 and CD3 + CD8 counts. These names assume that one has already gated to lymphocytes only. Lymphocytes are identified by CD45 markers. So a CD45+CD3+CD4+ is a more complicated way to name CD3+C4+ cells and in the context of looking for CD4 helper T cells they are the same . The same applies to other flow cytometer measures that are looking only at lymphocytes (B-cells, NK cells, etc).
 
 
  Part: Cells.CD3+CD4+
  HIV infection decreases the number of CD3+ CD4+ lymphocytes (also called CD4 T cells or T4 helper cells) while increasing (momentarily) the numbers of CD3+CD8+ lymphocytes (called CD8 T lymphocytes or cytotoxic T cells). Thus the ratio of CD4/CD8 lymphocytes is decreased. These counts are used for prognostic purposes and to guide in the retroviral therapy. CDC has emphasized since 1997 that the number of CD3+ lymphocytes is necessary in addition to the number of CD4+ cells to reliably identify the T4 helper cells and the number of CD8+ cells. Laboratory reports that include only CD4 or only CD8 in their nomenclature are most likely really measuring CD3+CD4+ cells and CD3+CD8+ cells, respectively.
 
 
  Part: CD4
  Found on helper T-cells; weakly expressed on monocytes.
Associated with some mature T-cell neoplasms, including most cases of T-cell CLL/prolymphocytic leukemia, peripheral
T-cell lymphoma, adult T-cell leukemia/lymphoma and Sézary syndrome/mycosis fungoides
 
 

BASIC ATTRIBUTES
  Class/Type: CELLMARK/Lab
  First Released in Version: 2.66
  Last Updated in Version: 2.66
  Order vs. Obs.: Both
  Status: Active

PARTS

Part Type    Part No.  Part Name   
Component   LP14441-7  Cells.CD3+CD4+   [CD3+CD4+ (T4 helper) cells] 
Property   LP6836-3  NCnc   [Number Concentration] 
Time   LP6960-1  Pt   [Point in time (spot)] 
System   LP7057-5  Bld   [Blood] 
Scale   LP7753-9  Qn 
Method   LP217198-3  IA.rapid   [Rapid immunoassay] 
Fragments for synonyms   LP14443-3  CD4 

LANGUAGE VARIANTS
  Chinese (CHINA)  (From: Regenstrief-generated full translation based on part translation provided by Lin Zhang, A LOINC volunteer from China)
 
  细胞.CD3+​CD4+​:计数型浓度:时间点:全血:定量型:免疫测定法.快速细胞.CD3+​CD4+​:计数型浓度:时间点:全血:定量型:免疫测定法.快速
  Dutch (NETHERLANDS)  (From: Regenstrief-generated full translation based on part translation provided by NVKC, Dutch Society for Clinical Chemistry and Laboratory Medicine, The Netherlands)
 
  cellen.CD3+​CD4+​:aantal/​volume:moment:bloed:kwantitatief:immunoassay.sneltestcellen.CD3+​CD4+​:aantal/​volume:moment:bloed:kwantitatief:immunoassay.sneltest
  Estonian (ESTONIA)  (From: Regenstrief-generated full translation based on part translation provided by Estonian E-Health Foundation)
 
  Rakud.CD3+​CD4+​:NCnc:Pt:B:Qn:IA.rapidRakud.CD3+​CD4+​:NCnc:Pt:B:Qn:IA.rapid
  French (BELGIUM)  (From: Regenstrief-generated full translation based on part translation provided by Jean M. Prevost, MD, Biopathology)
 
  Cellules.CD3+​CD4+​:Concentration numérique:Temps ponctuel:Sang:Quantitatif:IA.rapidCellules.CD3+​CD4+​:Concentration numérique:Temps ponctuel:Sang:Quantitatif:IA.rapid
  French (CANADA)  (From: Regenstrief-generated full translation based on part translation provided by Canada Health Infoway Inc.)
 
  Cellules.CD3+​CD4+​:Concentration numérique:Temps ponctuel:Sang:Quantitatif:IA.rapideCellules.CD3+​CD4+​:Concentration numérique:Temps ponctuel:Sang:Quantitatif:IA.rapide
  Italian (ITALY)  (From: Regenstrief-generated full translation based on part translation provided by Consiglio Nazionale delle Ricerche)
 
  Cellule.CD3+​CD4+​:NCnc:Pt:Sangue:Qn:IA.rapidoCellule.CD3+​CD4+​:NCnc:Pt:Sangue:Qn:IA.rapido
  Russian (RUSSIAN FEDERATION)  (From: Regenstrief-generated full translation based on part translation provided by Yaroslavl State Medical Academy)
 
  Клетки.CD3+​CD4+​:КолОб:ТчкВрм:Кр:Колич:IA.rapidКлетки.CD3+​CD4+​:КолОб:ТчкВрм:Кр:Колич:IA.rapid
  Spanish (SPAIN)  (From: Regenstrief-generated full translation based on part translation provided by the Clinical Laboratory Committee of SERVICIO EXTREMEÑO DE SALUD, with the support of BITAC MAP.)
 
  Células CD3+​CD4+​:Concentración de número:Punto temporal:Sangre:Qn:IA.rapidCélulas CD3+​CD4+​:Concentración de número:Punto temporal:Sangre:Qn:IA.rapid
  Turkish (TURKEY)  (From: Regenstrief-generated full translation based on part translation provided by LOINC Turkish Translation Group and the Turkish Ministry of Health)
 
  Hücreler.CD3+​CD4+​:SayKons:Zmlı:Kan:Kant:İA.hızlıHücreler.CD3+​CD4+​:SayKons:Zmlı:Kan:Kant:İA.hızlı

RELATED NAMES
  # EIA QNT
  ABS ELFA Quan
  absolute ELISA Quant
  absolutes Enzyme immunoassay Quantitative
  Blood Helper T cells Random
  CD3 Cells IAA SUDS
  CD3+CD4+ Cells Inducer T cells T3
  CD3-CD4+ L3T4 T4
  CD4+ T cells Leu3 T-4
  Cell Leu-3 T4 helper/inducer cells
  CELL MARKERS Leu4 W3/25
  Cellularity Leu-4 WB
  Cnt MEIA Whole blood
  Count Number concentration  
  Count/volume Number Concentration (count/vol)  
  CT Point in time  

EXAMPLE UNITS
  Unit  Source Type
  /uL  EXAMPLE UCUM UNITS 

UNITS (INTERNAL DETAILS)
  Source Type:  EXAMPLE UCUM UNITS 
  Unit:  /uL 

CHANGE HISTORY
  Change Type: ADD

INTERNAL FIELDS
  Detail Page Created On: 6/20/2019 8:53:48 AM
  Long Common Name: CD3+CD4+ (T4 helper) cells [#/volume] in Blood by Rapid immunoassay
  Shortname: CD3+CD4+ Cells # Bld IA.rapid
  Fully Specified Name: Cells.CD3+CD4+: NCnc: Pt: Bld: Qn: IA.rapid
     
  Component Word Count: 3
  ID: 100278
  Status (Raw): ACTIVE