92896-0  Aldosterone [Mass/​volume] in Serum or Plasma by Radioimmunoassay (RIA)Aldosterone [Mass/​volume] in Serum or Plasma by Radioimmunoassay (RIA)Aldosterone: MCnc: Pt: Ser/​Plas: Qn: RIA  

NAME
  Fully Specified Name: 
Component   Property   Time   System   Scale   Method
Aldosterone  MCnc  Pt  Ser/Plas  Qn  RIA
  Long Common Name:  Aldosterone [Mass/volume] in Serum or Plasma by Radioimmunoassay (RIA)
  Short Name:  Aldost SerPl RIA-mCnc
  Display Name:  Aldosterone RIA [Mass/Vol]

TERM DEFINITION/DESCRIPTION(S)
  Aldosterone concentration measured by radioimmunoassay (RIA) and chemiluminescent immunoassay are well-correlated; however, they have different reference ranges. [PMID: 29115296]
This term is for aldosterone measurement by RIA. For aldosterone concentration measured by immunoassay methods such as chemiluminescence, see [LOINC: 92897-8] .
 
 

PART DEFINITION/DESCRIPTION(S)
  Part: Aldosterone
  Used to detect hyper and hypo aldosteronisnm. Hypoaldosteronism can occur in any condition that causes destruction or dysfunction of the adrenal gland.1,2,4 Hypoaldosterism can be due to primary adrenal insufficiency , congenital adrenal hypoplasia, acquired secondary aldosterone deficiency (hyporeninemic hypoaldosteronism), and acquired Hyporeninemic hypoaldosteronism is the most common form of isolated hypoaldosteronism and is results from impaired renin release from the kidney. Congenital hypoaldosteronism caused by inherited enzymatic defects in aldosterone biosynthesis are rare. Corticosterone methyloxidase I (CMO I) deficiency is associated with elevated serum levels of corticosterone and low levels of 18-hydroxy-corticosterone and aldosterone. Corticosterone methyloxidase II (CMO II) deficiency produces high levels of 18-hydroxy-corticosterone, the immediate precursor of aldosterone.
Acquired primary hypoaldosteronism can be caused by the administration of heparin. Also, persistently hypotensive, critically ill patients with sepsis, pneumonia, peritonitis, cholangitis, and liver failure can have inappropriately low plasma aldosterone concentrations in relation to elevated plasma renin activity. Primary hyperaldosteronism, also referred to as Conn syndrome, is due to overproduction of aldosterone by one or both of the adrenal glands. Some recent studies suggest that 10% to 15% of Hyper thyroidism cases are due to (or associated with ) primary hyperaldosteronism. Secondary hyperaldosteronism is relatively common and can occur as the result of any condition that decreases blood flow to the kidneys (ie, renal artery stenosis), decreases blood pressure, or lowers plasma sodium levels. Secondary hyperaldosteronism may also be seen with cirrhosis, congestive heart failure. and toxemia of pregnancy. Several studies have suggested that high-normal aldosterone levels predict development of high blood pressure in normotensive subjects and that increased aldosterone action contributes to hypertension, cardiovascular fibrosis, and cardiac hypertrophy.
 
 
  Part: Aldosterone
  Aldosterone is a steroid hormone produced by the outer-section (zona glomerulosa) of the adrenal cortex in the adrenal gland to regulate sodium and potassium balance in the blood. It is synthesized from cholesterol by aldosterone synthase, which is absent in other sections of the adrenal gland. It is the sole endogenous member of the class of mineralocorticoids. Acting on mineralocorticoid receptors (MR) on principal cells in the collecting ducts of the kidneys, it increases the permeability of their apical (luminal) membrane to potassium and sodium and activates their basolateral Na+K+ pumps, stimulating ATP hydrolysis, reabsorbing sodium (Na+) ions and water into the blood, and excreting potassium (K+) ions into the urine. Aldosterone also stimulates H+ secretion by intercalated cells in the collecting duct, regulating plasma bicarbonate (HCO3-) levels and its acidbase balance.
  Copyright: Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details.
 
 

BASIC ATTRIBUTES
  Class/Type: CHEM/Lab
  First Released in Version: 2.66
  Last Updated in Version: 2.66
  Order vs. Obs.: Both
  Status: Active

MEMBER OF THESE EQUIVALENCE GROUPS
  LG5179-9  Aldosterone|MCnc|Pt|ANYBldSerPl

PARTS

Part Type    Part No.  Part Name   
Component   LP14377-3  Aldosterone 
Property   LP6827-2  MCnc   [Mass Concentration] 
Time   LP6960-1  Pt   [Point in time (spot)] 
System   LP7576-4  Ser/Plas   [Serum or Plasma] 
Scale   LP7753-9  Qn 
Method   LP6493-3  RIA   [Radioimmunoassay (RIA)] 

LANGUAGE VARIANTS
  Chinese (CHINA)  (From: Regenstrief-generated full translation based on part translation provided by Lin Zhang, A LOINC volunteer from China)
 
  醛固酮:质量浓度:时间点:血清/​血浆:定量型:放射免疫分析法醛固酮:质量浓度:时间点:血清/​血浆:定量型:放射免疫分析法
  Dutch (NETHERLANDS)  (From: Regenstrief-generated full translation based on part translation provided by NVKC, Dutch Society for Clinical Chemistry and Laboratory Medicine, The Netherlands)
 
  aldosteron:massa/​volume:moment:serum of plasma:kwantitatief:RIAaldosteron:massa/​volume:moment:serum of plasma:kwantitatief:RIA
  Estonian (ESTONIA)  (From: Regenstrief-generated full translation based on part translation provided by Estonian E-Health Foundation)
 
  Aldosteroon:MCnc:Pt:S/​P:Qn:RIAAldosteroon:MCnc:Pt:S/​P:Qn:RIA
  French (BELGIUM)  (From: Regenstrief-generated full translation based on part translation provided by Jean M. Prevost, MD, Biopathology)
 
  Aldostérone:Concentration de masse:Temps ponctuel:Sérum/​Plasma:Quantitatif:RIAAldostérone:Concentration de masse:Temps ponctuel:Sérum/​Plasma:Quantitatif:RIA
  French (CANADA)  (From: Regenstrief-generated full translation based on part translation provided by Canada Health Infoway Inc.)
 
  Aldostérone:Concentration de masse:Temps ponctuel:Sérum/​Plasma:Quantitatif:RIAAldostérone:Concentration de masse:Temps ponctuel:Sérum/​Plasma:Quantitatif:RIA
  Italian (ITALY)  (From: Regenstrief-generated full translation based on part translation provided by Consiglio Nazionale delle Ricerche)
 
  Aldosterone:MCnc:Pt:Siero/​Plasma:Qn:RIAAldosterone:MCnc:Pt:Siero/​Plasma:Qn:RIA
  Russian (RUSSIAN FEDERATION)  (From: Regenstrief-generated full translation based on part translation provided by Yaroslavl State Medical Academy)
 
  Альдостерон:МассКонц:ТчкВрм:Сыв/​Плаз:Колич:РИААльдостерон:МассКонц:ТчкВрм:Сыв/​Плаз:Колич:РИА
  Spanish (SPAIN)  (From: Regenstrief-generated full translation based on part translation provided by the Clinical Laboratory Committee of SERVICIO EXTREMEÑO DE SALUD, with the support of BITAC MAP.)
 
  Aldosterona:Concentración de masa:Punto temporal:Suero o Plasma:Qn:Radioinmunoensayo (RIA)Aldosterona:Concentración de masa:Punto temporal:Suero o Plasma:Qn:Radioinmunoensayo (RIA)
  Turkish (TURKEY)  (From: Regenstrief-generated full translation based on part translation provided by LOINC Turkish Translation Group and the Turkish Ministry of Health)
 
  Aldosteron:KütlKons:Zmlı:Ser/​Plaz:Kant:RIAAldosteron:KütlKons:Zmlı:Ser/​Plaz:Kant:RIA

RELATED NAMES
  Chemistry QNT SerPl
  Level Quan SerPlas
  Mass concentration Quant Serum
  Pl Quantitative Serum or plasma
  Plasma RADIOIMMUNOASSAY SR
  Plsm Random  
  Point in time SerP  

EXAMPLE UNITS
  Unit  Source Type
  ng/dL  EXAMPLE UCUM UNITS 

UNITS (INTERNAL DETAILS)
  Source Type:  EXAMPLE UCUM UNITS 
  Unit:  ng/dL 

CHANGE HISTORY
  Change Type: ADD

INTERNAL FIELDS
  Detail Page Created On: 6/20/2019 8:58:21 AM
  Long Common Name: Aldosterone [Mass/volume] in Serum or Plasma by Radioimmunoassay (RIA)
  Shortname: Aldost SerPl RIA-mCnc
  Fully Specified Name: Aldosterone: MCnc: Pt: Ser/Plas: Qn: RIA
     
  Component Word Count: 1
  ID: 100476
  Status (Raw): ACTIVE